Table 4.
Genetic Moderation of Depressive Reactivity to Victimization: DRD2 TaqIA
| VictimizationOnly | Additive Model | Interaction Model | ||||
|---|---|---|---|---|---|---|
| B (SE) | p-value | B (SE) | p-value | B (SE) | p-value | |
| Fixed Effects | ||||||
| Intercept | .01 (.05) | .91 | −.06 (.08) | .41 | −.06 (.07) | .44 |
| Grade | .01 (.02) | .67 | .01 (.02) | .67 | .01 (.02) | .68 |
| White | .13 (.05) | .01 | .13 (.05) | .01 | .13 (.05) | .01 |
| Male | −.18 (.05) | <.001 | −.20 (.05) | <.001 | −.20 (.05) | <.001 |
| Victimization | .29 (.08) | <.001 | .27 (.08) | <.001 | .19 (.22) | .37 |
| DRD2 TaqIA | .10 (.08) | .19 | .10 (.08) | .22 | ||
| Victimization* DRD2 TaqIA | .10 (.26) | .68 | ||||
| Random Effects | ||||||
| Intercept Variance | .65 (.07) | <.001 | .66 (.07) | <.001 | .66 (.07) | <.001 |
| Grade Variance | .03 (.01) | .02 | .03 (.01) | .01 | .03 (.01) | .01 |
| Victimization Variance | .47 (.13) | <.01 | .36 (.13) | <.01 | .37 (.13) | <.01 |
| Residual Variance | .35 (.13) | <.01 | .47 (.02) | <.001 | .47 (.01) | .01 |
| Model Fit | ||||||
| AIC | 8228.8 | 8103.4 | 8118.9 | |||
| BIC | 8264.2 | 8168.9 | 8154.1 | |||
Note. DRD2 TaqIA is scored additively with each A2 allele = .5 and each A1 allele = 0 (for a total score between 0–1). Grade is centered at 8th grade, depressive symptoms are standardized, andvictimization is scored as present or absent. AIC = Akaike Information Criterion (lower is better). BIC = Bayesian Information Criterion (lower is better). Substantively interesting parameter estimates are bolded.