Table 2.

Lopinavir concentrations, time of sampling, body weight and lopinavir dose, by study week

	Weeks
	12 (n=74)	24 (n=132)	36 (n=128)	52 (n=100)	≥52 (n=53)
LPV, mg/l	7.03 (3.36–10.95; 0.08–34.40)	8.21 (4.18–12.20; 0.08–32.50)	8.57 (4.97–13.00; 0.08–30.00)	8.22 (3.12–12.00; 0.08–33.60)	6.76 (2.59–13.20; 0.08–26.60)
Samples <1 mg/l, n (%)	13 (18)	16 (12)	18 (14)	16 (16)	16 (30)
Samples <4 mg/l, n (%)	17 (23)	16 (17)	23 (18)	19 (19)	16 (30)
Time after dose, h	3.58 (3.00–4.17; 1.25–9.00)	3.50 (2.50–4.17; 0.50–6.41)	3.41 (2.58–4.25; 1.25–6.91)	3.50 (2.75–4.42; 0.42–6.08)	3.33 (2.37–4.23; 0.58–6.67)
Total body weight, kg	8.38 (7.49–9.50; 4.20–12.50)	9.25 (8.04–10.25; 4.03–15.44)	9.80 (8.62–10.80; 5.85–16.40)	10.10 (8.90–11.00; 5.52–16.40)	10.60 (9.75–11.93; 6.30–15.55)
LPV dose, mg/m2	225.24 (220.17–232.75; 135.48–287.89)	221.83 (213.20–229.26; 174.41–442.48)	224.04 (216.72–231.26; 195.95–355.40)	224.72 (216.67–231.73; 192.02–321.08)	224.89 (221.84–230.51; 204.46–302.30)

Data are median (IQR; range), unless otherwise indicated. LPV, lopinavir.