Table I.

Trimethoprim/sulfamethoxazole dosing algorithm.^*

Creatinine clearance	High dose	Low dose
≥30 mL/min	15–20 mg/kg/d in 3–4 divided doses	<15 mg/kg/d in 2–4 divided doses
<30 mL/min†	7–10 mg/kg/24 h in 2 divided doses	<7 mg/kg/24 h divided q12h–q24h

^⁎Dose based on trimethoprim component.

^†Patients receiving dialysis were recommended to receive the dose indicated for patients with CrCl < 30 ml/min with the dose scheduled after dialysis on dialysis days.