Table II.
Baseline demographic characteristics.
| Characteristic | Peak (n = 119) |
Modified peak (n = 305) |
||||||
|---|---|---|---|---|---|---|---|---|
| Total | Low-dose (n = 82) | High-dose (n = 37) | P | Total | Low-dose (n = 195) | High-dose (n= 110) | P | |
| Male gender* | 82 (68.9) | 55 (67.1) | 27 (73.0) | 0.52 | 208 (68.2) | 134 (68.7) | 74 (67.3) | 0.79 |
| Age† | 65.2 (53.8–74.0) | 64.5 (53.8–74.1) | 68.2 (54.8–72.8) | 0.91 | 63.6 (49.8–72.6) | 64.6 (53.5–74.1) | 60.7 (45.5–69.4) | 0.0067 |
| Race* | ||||||||
| White | 102 (85.7) | 71 (86.6) | 31 (83.8) | 0.6860 | 260 (85.2) | 167 (85.6) | 93 (84.5) | 0.7956 |
| Hispanic | 2 (1.7) | 2 (2.4) | 0 (0) | 4 (1.3) | 4 (2.1) | 0 (0) | ||
| African American | 1 (0.8) | 1 (1.2) | 0 (0) | 2 (0.7) | 2 (1.0) | 0 (0) | ||
| Asian/Pacific Islander | 0 (0) | 0 (0) | 0 (0) | 2 (0.7) | 0 (0) | 2 (1.8) | ||
| Native American | 0 (0) | 0 (0) | 0 (0) | 1 (0.3) | 1 (0.5) | 0 (0) | ||
| Other/not reported | 14 (11.8) | 8 (9.8) | 6 (16.2) | 36 (11.8) | 21 (10.8) | 15 (13.6) | ||
| Weight† (kg) | 74.0 (63.3–85.8) | 75.1 (65.8–87.7) | 71.5 (60.4–79.8) | 0.058 | 75.4 (63.4–88.1) | 74.8 (64.6–90.0) | 73.3 (61.1–84.5) | 0.087 |
| Body mass index† | 24.8 (21.5–27.9) | 25.3 (22.0–29.7) | 23.0 (20.3–25.1) | 0.011 | 25.0 (21.9–29.2) | 25.4 (22.7–30.1) | 24.6 (21.5–27.9) | 0.036 |
| Creatinine clearance‡ | 68.4 (44.9–97.6) | 65.3 (37.5–95.9) | 78.5 (52.0–106.8) | 0.065 | 69.8 (46.3–103.3) | 64.1 (39.6–94.1) | 78.0 (53.2–110.5) | 0.001 |
| Comorbidities | ||||||||
| Chronic kidney disease* | 25 (21.0) | 17 (20.7) | 8 (21.6) | 0.91 | 62 (20.3) | 42 (21.5) | 20 (18.3) | 0.48 |
| Dialysis* | 17 (14.3) | 15 (18.3) | 2 (5.4) | 0.063 | 42 (13.8) | 33 (16.9) | 9 (8.2) | 0.033 |
| Hemodialysis | 11 (9.2) | 11 (13.4) | 0 (0) | 27 (8.9) | 22 (11.3) | 5 (4.5) | ||
| Continuous venovenous hemofiltration | 6 (5.0) | 4 (4.9) | 2 (5.4) | 15 (4.9) | 11 (5.6) | 4 (3.6) | ||
| Diabetes* | 30 (25.2) | 24 (29.3) | 6 (16.2) | 0.13 | 70 (23.0) | 56 (28.7) | 14 (12.7) | 0.0014 |
| Immunocompromised* | 107 (89.9) | 71 (86.6) | 36 (97.3) | 0.073 | 267 (87.5) | 161 (82.6) | 106 (96.4) | 0.0005 |
⁎
Values are given as n (%).
†
Values are given as median (interquartile range).
‡
Values are given as median (mL/min).