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. 2014 Nov 14;20(42):15467–15475. doi: 10.3748/wjg.v20.i42.15467

Figure 1.

Figure 1

Representative model for tumor angiogenesis induced by hepatocytes growth factor/Scater factor-Met signaling. Intrinsically hepatocytes growth factor/Scater factor (HGF/SF) activates Met receptor on the surface of host endothelial cells leading to cell proliferation and migration. Extrinsically, HGF/SF-Met signaling turns on the angiogenic switch by simultaneous upregulation of pro-angiogenic vascular endothelial growth factors (VEGF) expression and down regulation of thrombospondin 1 (TSP-1) expression from the tumor cells.