Table 4.
Histopathological features of pediatric and adult nonalcoholic fatty liver disease cases n (%)
| Item | Score/code | Pediatric (n = 34) | Adult (n = 23) |
| Steatosis | |||
| Grade | 0 (< 5%) | 0 (0) | 0 (0) |
| 1 (5%-33%) | 10 (29) | 7 (30) | |
| 2 (> 33%-66%) | 15 (45) | 14 (61) | |
| 3 (> 66%) | 9 (26) | 2 (9) | |
| Location | Zone 3 | 12 (35) | 14 (61) |
| Zone 1 | 0 (0) | 0 (0) | |
| Azonal | 5 (15) | 4 (17) | |
| Panacinar | 17 (50) | 5 (22) | |
| Fibrosis | |||
| Perisinusoidal1 | 0 (none) | 19 (56) | 6 (26) |
| 1 (mild) | 10 (29) | 8 (35) | |
| 2 (moderate) | 5 (15) | 9 (39) | |
| Periportal | 0 (none) | 18 (53) | 13 (57) |
| 1 (mild) | 13 (38) | 6 (26) | |
| 2 (moderate) | 2 (6) | 2 (9) | |
| 3 (severe) | 1 (3) | 1 (4) | |
| 4 (cirrhosis) | 0 (0) | 1 (4) | |
| Stage | 0 (none) | 12 (34) | 6 (26) |
| 1A (mild, zone 3, perisinusoidal) | 4 (12) | 5 (22) | |
| 1B (moderate, zone 3, perisinusoidal) | 2 (6) | 2 (9) | |
| 1C (periportal) | 7 (21) | 0 (0) | |
| 2 (perisinusoidal + periportal) | 6 (18) | 5 (22) | |
| 3 (bridging fibrosis) | 3 (9) | 4 (17) | |
| 4 (cirrhosis) | 0 (0) | 1 (4) | |
| Inflammation | |||
| Lobular | 0 (no foci) | 7 (21) | 2 (9) |
| 1 (< 2 foci per 200 × field) | 18 (52) | 13 (56) | |
| 2 (2-4 foci per 200 × field) | 7 (21) | 6 (26) | |
| 3 (> 4 foci per 200 × field) | 2 (6) | 2 (9) | |
| Portal | 0 (none) | 11 (32) | 10 (43) |
| 1 (mild) | 14 (42) | 11 (48) | |
| 2 (moderate) | 9 (26) | 2 (9) | |
| 3 (severe) | 0 (0) | 0 (0) | |
| Ballooning | 0 (none) | 16 (47) | 6 (26) |
| 1 (few) | 10 (29) | 13 (57) | |
| 2 (many/prominent) | 8 (24) | 4 (17) | |
| Diagnosis | Not NASH | 8 (24) | 4 (17) |
| Borderline zone 1 NASH | 7 (21) | 2 (9) | |
| Borderline zone 3 NASH | 5 (15) | 5 (22) | |
| Definite NASH | 14 (40) | 12 (52) |
1
Perisinusoidal fibrosis was significantly milder in pediatric cases than in adult cases. Borderline zone 1 NASH corresponds to type 2 NASH[52]. NASH: Nonalcoholic steatohepatitis.