Table 1.
Position emission tomography/computed tomography in detection of malignant pancreatic tumors
| Ref. | Study design | Maligancy/all (n) | SUV (max) of malignant lesions (mean ± SD) | SUV (max) of benign lesions (mean ± SD) | Cutoff value | SE | SP | PPV | NPV | LR(+) | LR(-) | Accuracy |
| Keogan et al[24] | R | 25/37 | 5.4 | 1.4 | - | 88.00% | 83.33% | 91.67% | 76.92% | 5.28 | 0.144 | 86.49% |
| 1Rose et al[23] | R | 52/65 | 5.0 ± 1.2 | 0.85 ± 0.1 | - | 92.30% | 84.62% | 96.00% | 73.33% | 6 | 0.09 | 90.76% |
| 1Delbeke et al[22] | R | 52/65 | 5.1 ± 2.6 | 0.85 ± 1.7 | 3.0 | 92.30% | 84.62% | 96.00% | 73.33% | 6 | 0.09 | 90.76% |
| 2Lemke et al[20] | R | 64/100 | - | - | 3.5 | 84.37% | 61.11% | 79.41% | 68.75% | 2.17 | 0.26 | 76.00% |
| 1Lytras et al[18] | R | 72/112 | - | - | -3 | 73.00% | 60.00% | 80.00% | 49.00% | - | - | 64.00% |
| Heinrich et al[32] | P | 46/59 | - | - | - | 89.13% | 69.23% | 91.11% | 64.29% | 2.89 | 0.16 | 84.75% |
| Nishiyama et al[31] | R | 55/86 | 5.75 ± 2.69 | 3.69 ± 1.58 | 3.5 | 89.09% | 70.97% | 84.48% | 78.57% | 3.07 | 0.15 | 82.56% |
| Bang et al[30] | R | 93/102 | 5.1 ± 2.1 | 3.2 ± 1.8 | - | 96.77% | 77.78% | 97.82% | 70.00% | 4.35 | 0.04 | 95.09% |
| Kauhanen et al[29] | P | 19/38 | 4.85 ± 2.77 | 2.25 ± 0.75 | 2.6 | 85.00% | 94.44% | 94.44% | 85.00% | 15.3 | 0.16 | 89.47% |
| Buchs et al[28] | R | 36/45 | 6.5 ± 4.5 | 3.4 ± 3.1 | - | 72.00% | 33.30% | 80.00% | 25.00% | - | - | 64.00% |
| 4Buchs et al[28] | R | 36/45 | 6.5 ± 4.5 | 3.4 ± 3.1 | - | 96.00% | 66.60% | 92.30% | 80.00% | - | - | 90.30% |
| Santhosh et al[27] | R | 57/87 | 8.64 ± 5.21 | 4.86 ± 4.54 | 2.8 | 96.36% | 78.57% | 94.64% | 84.61% | 4.49 | 0.05 | 92.75% |
| Hu et al[26] | R | 54/80 | 6.3 ± 2.4 | 2.9 ± 2.0 | 3.5 | 96.29% | 72.72% | 89.65% | 88.89% | 3.53 | 0.05 | 89.47% |
1
Fluorodeoxyglucose-position emission tomography (FDG-PET) scan without computed tomography (CT);
2
Voxel-based retrospective registration and fusion of CT and PET were performed with software. PET imaging and CT were not taken at the same time;
3
Lesions measured visually;
4
Data obtained with extra scan of enhanced PET/CT. SE: Sensitivity; SP: Specificity; NPV: Negative predictive value; PPV: Positive predictive value; R: Retrospective study; P: Prospective study.