Table 2.
Body weight, organ weights, serum biochemistry parameters and oxidative stress parameters
| Groups | Normal | Alcohol |
Alcohol with CGX treatment |
CGX 200 | |
| 100 | 200 | ||||
| Body mass (g) | 347.3 ± 15.6 | 325.4 ± 20.4a | 327.8 ± 24.6 | 329.5 ± 16.0 | 332.3 ± 16.5 |
| Liver mass (g) | 10.2 ± 0.7 | 10.1 ± 1.5 | 9.3 ± 1.2 | 9.6 ± 0.7 | 9.2 ± 0.6 |
| Spleen mass (g) | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.8 ± 0.1 |
| Liver mass (%) | 2.9 ± 0.1 | 3.1 ± 0.5 | 2.8 ± 0.3 | 2.9 ± 0.1 | 2.8 ± 0.1 |
| Spleen mass (%) | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.2 ± 0.0 | 0.2 ± 0.0 |
| AST (IU/L) | 119.7 ± 18.1 | 226.3 ± 120.2a | 125.1 ± 18.1c | 105.3 ± 9.8c | 106.7 ± 5.2 |
| ALT (IU/L) | 45.8 ± 2.5 | 91.0 ± 39.5a | 70.3 ± 10.9c | 54.2 ± 6.5c | 45.7 ± 7.7 |
| ALP (IU/L) | 203.0 ± 29.7 | 269.9 ± 111.2 | 190.7 ± 33.4 | 174.9 ± 17.3 | 162.8 ± 20.0a |
| LDH (IU/L) | 1406.4 ± 68.3 | 1646.1 ± 224.3a | 1338.0 ± 444.6 | 1009.6 ± 164.1d | 925.2 ± 115.2a |
Rats were orally administered with alcohol (10 mL of 30% ethanol/kg) with/without CGX (100 or 200 mg/kg) for 4 wk. Body weight were recorded twice weekly during experiment. At the end of the experiment, whole blood was collected and liver and spleen were removed. Data were expressed as mean ± SD (n = 6-9);
a
P < 0.05 vs normal group;
c
P < 0.05 vs alcohol group;
d
P < 0.01 vs alcohol group. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; LDH: Lactic dehydrogenase.