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. 2014 Jul 9;39(13):2963–2973. doi: 10.1038/npp.2014.142

Figure 1.

Figure 1

Effect of neonatal ventral hippocampus (nVH) lesion on extracellular signal-regulated kinase 1/2 (ERK1/2) activation in prefrontal cortex (PFC) slices. (a) Representative western blot signals using antibodies for (phospho) p-ERK1/2, (total) t-ERK1/2 and α-tubulin. (b and c) show mean±SEM ratio of relative optical density (ROD) of p-ERK1/2 vs t-ERK1/2, as well as t-ERK1/2 vs tubulin. Incubation with α-1AR agonist phenylephrine (PE) stimulates p-ERK1/2 in the sham but not lesioned animals (**p=0.001). PE-induced p-ERK1/2 stimulation is α-1AR dependent as it is completely blocked by antagonist prazosin (Pr; ##p=0.001, sham PE vs sham PE+Pr).