Skip to main content
. 2014 Jul 9;39(13):2963–2973. doi: 10.1038/npp.2014.142

Figure 2.

Figure 2

Norepinephrine (NE)-induced long-term depression (LTD) in the prefrontal cortex (PFC) is abolished by neonatal ventral hippocampus (nVH)-lesion. (a) Left figure shows the infralimbic region of the PFC (dotted line circle) that was examined in this study. (a, b) The schematic diagrams depicting the placement of recording and stimulating electrodes. Whole-cell excitatory postsynaptic potentials (EPSPs) evoked by stimulating either the layer I/II (EPSPsuperficial) or layer VI cortical inputs (EPSPdeep) were recorded from layer V pyramidal neurons. (c) A brief NE treatment (20 μM, 10 min) induced LTD of EPSPsuperficial in slices obtained from sham-operated rats. *p=0.017 vs baseline EPSP before NE application. (d) Note that similar NE treatment did not produce long-lasting change of EPSPdeep. (e, f) NE failed to induce LTD of EPSPsuperficial and EPSPdeep in slices obtained from nVH lesion rats. (g) Using slices obtained from control rats, NE-LTD of EPSPsuperficial can be abolished by α-1 adrenergic receptor antagonist prazosin (10 μM). (h) A short Tat-GluR23Y peptide, which is known to inhibit the endocytosis of AMPA receptor, was delivered to layer V pyramidal neurons recorded from slices of control rats through whole-cell recording. NE failed to induce LTD of EPSPsuperficial in peptide-treated neurons.