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. 2014 Aug 6;39(13):3100–3111. doi: 10.1038/npp.2014.167

Figure 2.

Figure 2

Western blots of FMRP expression in control and AAV–FMRP-treated mice. (a) Representative western blots of the cerebral cortex, hippocampus, and striatum from individual mice injected with AAV–FMRP in the short arm where brain samples were collected at PND 31. (b) FMRP transgene expression in the long arms of the study at PND 60. (c) Quantification of samples from the short and long arms of the study as well as long-term (7 months) expression. Expression in injected Fmr1 KO mice was normalized to the GAPDH signal intensity and compared with age- and sex-matched PBS-injected wild-type brain regions (100% FMRP expression). The results are presented as the mean±SEM. (d) Representative western blots of Fmr1 KO mice 7 months after i.c.v. injection with AAV–FMRP.