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The LuxS/AI-2 signaling pathway. The lsrACDBFGE genes are transcribed in an operon, whereas lsrK and lsrR are divergently transcribed. LsrB binds AI-2 which is then imported by the Lsr ABC transport system. Inside the cell, AI-2 is phosphorylated by LsrK and is thought to interact with LsrR, relieving the repression of the lsr operon.
