Table 2. The overall rate of nonsynonymous (dN) to synonymous (dS) substitutions and sites under positive selection in the respective protein-coding genes.
PAML | FUBAR | |||||||
---|---|---|---|---|---|---|---|---|
M7 vs M8 | M8 vs M8a | |||||||
Gene | n | dN/dS (95% CI) | LRT (2Δl) | p-value | LRT (2Δl) | p-value | Positively selected sites | Positively selected sites |
N | 15 | 0.19 (0.13–0.28) | 0.053 | 0.97 | 0.037 | 0.85 | None | None |
P | 6 | 0.49 (0.34–0.68) | 1.99 | 0.37 | 1.88 | 0.17 | None | None |
M | 13 | 0.27 (0.18–0.39) | 10.9 | 0.004 | 10.9 | 0.001 | 331, 335 | 335 |
F | 19 | 0.17 (0.12–0.24) | 0 | 1 | 0 | 1 | None | None |
H | 16 | 0.20 (0.15–0.26) | 0 | 1 | 0 | 1 | None | None |
L | 8 | 0.16 (0.13–0.20) | 0 | 1 | 0 | 1 | None | None |
n:Number of sequences; LRT: likelihood ratio test statistic for null model versus alternative model; 2Δl: Differences in the likelihood scores of null and alternative models; Null models (Neutral model): M7 and M8a; Alternative model (Selection model): M8; Degrees of freedom for M7-M8 and M8-M8a are 2 and 1, respectively. Sites with p < 0.05 and posterior probability > 0.95 for PAML and FUBAR respectively are considered to be under positive selection. Sites that are detected to be under positive selection by both methods are in bold.