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. 2014 Nov 13;4:7027. doi: 10.1038/srep07027

Figure 1. ACE2 plays a critical role in 2013 influenza H7N9 virus-induced ALI.

Figure 1

(A) Downregulated ACE2 expression in the lungs of Hb01/H7N9 virus-infected mice. Lung tissue homogenates prepared from control and Hb01/H7N9 virus-infected WT mice on day 3 were analyzed by western blotting. (B) Plasma levels of Ang II in control and Hb01/H7N9 virus-infected ACE2 KO or WT mice on day 3 (n = 8). (C) Ang II levels in the lungs of control and Hb01/H7N9 virus-infected WT mice on day 3 were measured using enzyme immunoassays (n = 8). (D) Plasma levels of Ang II in healthy and H7N9 virus-infected patients were measured using enzyme immunoassays. *, p < 0.05; ** p < 0.01 between groups.