FIG. 11.

The neoadipogenesis within the TEC. (A) In the inflammation stage, the macrophage/mesenchymal stem cell (MSC) infiltration as well as inflammatory/angiogenic factor release. (B) The angiogenesis stage inflammation remarkably enhanced the angiogenesis and the extracellular matrix (ECM) expansion as well as the proliferation of perivascular cells. (C) In the adipogenesis stage, perivascular cells turned into adipose precursor cells and adipogenic differentiation began. (D) Finally, in the maturation stage, after the expansion of newly formed adipocyte tissue and ECM remodeling, the neoadipogenesis completed. Color images available online at www.liebertpub.com/tec