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Two modes of introducing nanoceria in a 3D agarose-based culture of chondrocytes. (A) In Study 1, nanoceria is embedded in the construct during casting (day 0) and interleukin-1α (IL-1α) is added to the culture media. (B) In Study 2, the growth medium is supplemented with nanoceria along with IL-1α. IL-1α was added fresh during each media change. 3D, three-dimensional. Color images available online at www.liebertpub.com/tea
