Table 3.
Severity of H1N1pdm infection in hospitalized patients regarding missense single-nucleotide polymorphisms of SFTPA2 and SFTPA1
| |
|
|
|
Statistical significance |
||||
|---|---|---|---|---|---|---|---|---|
| |
|
|
P
a
|
P
b
|
P
a
|
P
b
|
||
| |
|
|
OR (95% CI) |
OR (95% CI) |
OR (95% CI) |
OR (95% CI) |
||
| Polymorphism | Genotype frequencies | Genotype comparisons | Allele comparisons | |||||
|
rs1965708 (Q223K) |
CC
|
CA
|
AA
|
CC vs CA + AA
|
C vs A
|
|||
| ARF |
48 |
33 (0.69) |
15 (0.31) |
0 (0.00) |
0.027 |
0.018 |
0.006 |
0.006 |
| No ARF |
22 |
9 (0.41) |
10 (0.46) |
3 (0.14) |
3.18 (1.12-9.01) |
5.40 (1.34-21.71) |
3.09 (1.35-7.04) |
4.09 (1.5-11.13) |
| ARDS |
16 |
14 (0.88) |
2 (0.13) |
0 (0.00) |
0.018c |
0.017 |
0.014 |
0.006 |
| No ARDS |
54 |
28 (0.52) |
23 (0.43) |
3 (0.06) |
6.45 (1.35-31.25) |
7.81 (1.45-42.05) |
5.51 (1.24-24.51) |
17.68 (2.25-138.57) |
| Shock |
16 |
14 (0.88) |
2 (0.13) |
0 (0.00) |
0.018c |
0.018 |
0.014 |
0.007 |
| No shock |
54 |
28 (0.52) |
23 (0.43) |
3 (0.06) |
6.45 (1.35-31.25) |
7.64 (1.41-41.44) |
5.51 (1.24-24.51) |
17.16 (2.17-135.70) |
| MV |
24 |
20 (0.83) |
4 (0.17) |
0 (0.00) |
0.004 |
0.007 |
0.004 |
0.003 |
| No MV |
46 |
22 (0.48) |
21 (0.46) |
3 (0.07) |
5.46 (1.61-18.47) |
18.60 (2.23-155.24) |
4.57 (1.49-13.97) |
12.78 (2.39-68.42) |
| ICUe |
30 |
23 (0.77) |
7 (0.23) |
0 (0.00) |
0.014 |
0.019 |
0.010 |
0.031 |
| No ICUe |
40 |
19 (0.48) |
18 (0.45) |
3 (0.08) |
3.64 (1.27-10.42) |
2.98 (1.19-7.46) |
3.25 (1.29-8.16) |
2.43 (1.09-5.45) |
|
rs1059046 (T9N) |
AA
|
AC
|
CC
|
AA vs AC + CC
|
A vs C
|
|||
| ARF |
48 |
20 (0.42) |
24 (0.50) |
4 (0.08) |
0.020 |
0.011 |
0.017 |
0.005 |
| No ARF |
22 |
3 (0.14) |
14 (0.64) |
5 (0.23) |
4.52 (1.18-17.24) |
8.02 (1.61-39.98) |
2.40 (1.16-4.98) |
3.70 (1.48-9.30) |
| ARDS |
16 |
9 (0.56) |
6 (0.38) |
1 (0.06) |
0.023 |
0.014 |
- |
0.016 |
| No ARDS |
54 |
14 (0.26) |
32 (0.59) |
8 (0.15) |
3.68 (1.15-11.77) |
5.47 (1.42-21.13) |
- |
3.71 (1.28-10.72) |
| MV |
24 |
11 (0.46) |
12 (0.50) |
1 (0.04) |
- |
0.039 |
- |
0.016 |
| No MV |
46 |
12 (0.26) |
26 (0.57) |
8 (0.17) |
- |
3.59 (1.07-12.10) |
- |
2.97 (1.22-7.19) |
| ICUe |
30 |
14 (0.47) |
14 (0.47) |
2 (0.07) |
0.033 |
- |
0.036 |
- |
| No ICUe |
40 |
9 (0.23) |
24 (0.60) |
7 (0.18) |
3.01 (1.07-8.48) |
- |
2.11 (1.04-4.27) |
- |
|
rs1136450 (L50V) |
GG
|
GC
|
CC
|
CC vs GC + GG
|
G vs C
|
|||
| ARF |
48 |
21 (0.44) |
25 (0.52) |
2 (0.04) |
0.028c |
0.019 |
0.024 |
0.038 |
| No ARF |
22 |
5 (0.23) |
12 (0.55) |
5 (0.23) |
6,77 (1.20-38.22) |
19.80 (1.64-238.70) |
2.31 (1.11-4.81) |
2.60 (1.05-6.42) |
| MV |
24 |
11 (0.46) |
13 (0.54) |
0 (0.00) |
0.044 |
- |
- |
0.040 |
| No MV | 46 | 15 (0.33) | 24 (0.52) | 7 (0.15) | 1.62 (1.33-1.96) | - | - | 2.55 (1.04-6.22) |
aP value for the bivariate comparison calculated with the χ2 test. bP value for the multivariate analysis calculated with binary logistic regression, including the variables age, gender, risk factors, secondary bacterial pneumonia, and bacteremia. cap value by Fisher Exact test. dip value for the multivariate analysis calculated with binary logistic regression, including the variables age, gender, risk factors, and secondary bacterial pneumonia (bacteremia variable was excluded because it shows a co-lineal relation with the variable mechanical ventilation). ePatients who required (ICU) or did not require (No ICU) ICU admission, P value for the multivariate analysis calculated with conditional logistic regression stratified by hospital of origin, including the co variables age, gender, risk factors, secondary bacterial pneumonia, and bacteremia. Only those comparisons with P < 0.05 and significant odds ratios were included. OR (95% CI), Odds ratio (95% confidence interval); ARF, acute respiratory failure; ARDS, acute respiratory distress syndrome; MV, mechanical ventilation; ICU, intensive care unit.