Table 4.
Severity of H1N1pdm infection in hospitalized patients regarding haplotypes of SFTPA2
| |
|
|
|
Statistical significance |
||||
|---|---|---|---|---|---|---|---|---|
| |
|
|
P
a
|
P
b
|
P
a
|
P
b
|
||
| |
|
|
OR (95% CI) |
OR (95% CI) |
OR (95% CI) |
OR (95% CI) |
||
| Haplotype | Diplotype frequencies | Diplotype comparisons | Haplotype comparisons | |||||
|
1A
0
(AGC)
|
1A
0
/1A
0
|
1A
0
/rest |
Rest/rest |
1A
0
/1A
0
vs 1A
0
/rest + rest/rest |
1A
0
vs
rest |
|||
| ARF |
48 |
16 (0.33) |
27 (0.56) |
5 (0.10) |
0.031 |
0.045 |
0.023 |
0.022 |
| No ARF |
22 |
2 (0.09) |
14 (0.64) |
6 (0.27) |
5.00 (1.04-24.10) |
6.38 (1.04-38.97) |
2.30 (1.11-4.76) |
2.81 (1.16-6.77) |
| ARDS |
16 |
8 (0.50) |
7 (0.44) |
1 (0.06) |
0.020c |
0.013 |
0.029 |
0.016 |
| No ARDS |
54 |
10 (0.19) |
34 (0.63) |
10 (0.19) |
4,40.(1.33-14.56) |
5.44 (1.43-20.77) |
2.56 (1.08-6.02) |
3.41 (1.26-9.22) |
| MV |
24 |
11 (0.46) |
12 (0.50) |
1 (0.04) |
0.005 |
0.004 |
0.007 |
0.003 |
| No MV |
46 |
7 (0.15) |
29 (0.63) |
10 (0.22) |
4.72 (1.51-14.69) |
7.03 (1.83-26.95) |
2.78 (1.31-5.83) |
3.73 (1.55-9.00) |
|
1A
1
(CGA)
|
1A/1A
1
|
1A
1
/rest |
rest/rest |
1A1/1A1 + 1A1/restvsrest/rest |
1A
1
vs
rest |
|||
| ARF |
48 |
0 (0.00) |
11 (0.23) |
37 (0.77) |
0.009 |
0.0017 |
0.004 |
0.005 |
| No ARF |
22 |
2 (0.09) |
10 (0.46) |
10 (0.46) |
0.25 (0.08-0.73) |
0.08 (0.02-0.39) |
0.23 (0.11-0.68) |
0.21 (0.07-0.62) |
| ARDS |
16 |
0 (0.00) |
2 (0.12) |
14 (0.88) |
- |
0.040 |
- |
0.021 |
| No ARDS |
54 |
2 (0.04) |
19 (0.35) |
33 (0.61) |
- |
0.16 (0.03- 0.92) |
- |
0.12 (0.02-0.73) |
| MV |
24 |
0 (0.00) |
4 (0.17) |
20 (0.83) |
0.037 |
0.019 |
0.034 |
0.015 |
| No MV |
46 |
2 (0.04) |
17 (0.37) |
27 (0.59) |
0.28 (0.08-0.97) |
0.08 (0.01-0.66) |
0.31 (0.1-0.96) |
0.16 (0.04-0.70) |
| ICUe |
30 |
0 (0.00) |
4 (0.13) |
26 (0.87) |
0.003 |
0.015 |
0.003 |
0.029 |
| No ICUe | 40 | 2 (0.05) | 17 (0.43) | 21 (0.53) | 0.17 (0.05-0.58) | 0.25 (0.08-0.76) | 0.20 (0.07-0.62) | 0.32 (0.11-0.89) |
Only those comparisons with P < 0.05 and significant odds ratio were included. OR (95% CI), odds ratio (95% confidence interval); ARF, acute respiratory failure; ARDS, acute respiratory distress syndrome; MV, mechanical ventilation; ICU, intensive care unit.
aP value for the bivariate comparison calculated with the χ2 test. b + - + value for the multivariate analysis calculated with binary logistic regression, including the variables age, gender, risk factors, secondary bacterial pneumonia, and bacteremia. cP value by Fisher Exact test. dP value for the multivariate analysis calculated with binary logistic regression, including the variables age, gender, risk factors, and secondary bacterial pneumonia (bacteremia variable was excluded because it shows a co-lineal relation with the variable mechanical ventilation). ePatients who required (ICU) or did not require (No ICU) ICU admission, P value for the multivariate analysis calculated with conditional logistic regression stratified by hospital of origin, including the covariables age, gender, risk factors, secondary bacterial pneumonia, and bacteremia. Conventional haplotypes at SFTPA2 were identified on the basis of combinations of the polymorphism rs1059046 (T9N), rs17886395 (A91P), and rs1965708 (Q223K). “Rest” refers to the other haplotypes for each comparison.