Table 1.

List of differentiated genes within general function categories and their representation across different comparisons based on single gene analysis and in each cluster based for the hierarchical clustering analysis

General function categories	Comparisons					Cluster
Gene name (within families)
Cell protection and immunity	T0	BW	FW	MR	GRB	1	2	3	4	5	6	7
Alpha2-macroglobulin	1	~	1	1	~	_	_	_	_	_	_	_
*Aminopeptidase	5	1	12	15	6	4	1	_	7	1	_	_
Bactericidal/permeability-increasing protein	~	~	~	~	~	_	_	1	_	_	_	_
Complement component	2	~	1	~	1	_	_	1	_	_	_	_
Dipeptidyl peptidase 4	1	1	~	~	~	_	_	_	_	_	_	_
Elastase inhibitor	~	~	~	~	~	1	_	_	_	_	_	_
Heat shock protein	2	~	~	1	~	_	_	_	_	_	_	_
Hemolytic toxin avt-1	~	~	~	~	~	1	_	3	_	_	_	_
*Lactose-binding lectin I-2	~	~	~	~	~	_	_	2	_	_	_	_
Laminin receptor	1	~	~	~	1	_	_	_	_	_	_	_
*Lectin (β-galactoside-binding)	1	~	~	3	2	1	1	_	_	_	_	_
Lysozyme G	1	~	~	~	1	_	_	_	_	_	_	_
*Beta-2 Microglobulin	~	~	~	~	~	_	1	_	_	_	_	_
*Mucin	1	~	1	1	1	2	_	1	_	1	_	_
£*Myosin regulatory light chain kinase	1	1	~	~	~	_	_	_	_	_	_	_
Nattectin	~	~	~	~	~	_	_	_	_	11	_	_
*Pentraxin	~	1	1	1	~	_	1	_	_	_	_	_
Proteasome (link with ubiquitin)	1	~	~	1	1	_	_	1	_	_	_	_
*Serine (or cysteine) proteinase inhibitor, clade B	1	2	~	~	~	_	_	_	_	_	_	_
Superoxide dismutase	~	~	~	~	~	_	_	1	_	_	_	_
T-cell receptor beta chain	~	~	~	~	~	1	_	_	_	_	_	_
*Tumor necrosis α factor	~	~	~	~	~	1	_	_	_	_	_	_
Detoxification	T0	BW	FW	MR	GRB	1	2	3	4	5	6	7
Amine oxidase	~	~	2	~	1	_	_	_	_	_	_	_
*Glutathione S-transferase	1	1	~	~	1	_	_	1	_	_	_	_
*Metallothionein 1	~	~	1	1	~	_	_	_	_	_	_	_
Energy metabolism & respiration (digestion)	T0	BW	FW	MR	GRB	1	2	3	4	5	6	7
*Adenine nucleotide translocator	2	~	~	~	~	_	_	_	_	_	_	_
Adenylate cyclase	1	~	~	~	~	_	_	_	_	_	_	_
Ataxin	1	~	~	~	~	_	_	_	_	_	_	_
ATP synthase	1	~	~	1	1	1	_	_	_	_	_	_
ATP h + transporting f1	~	~	~	~	~	_	_	1	_	_	_	_
Chitinase	~	~	~	1	1	_	1	_	_	_	_	_
Cystatin	1	~	1	1	~	_	_	1	_	_	_	_
*Cytochrome c oxydase	22	10	7	3	17	10	_	6	_	_	_	_
Enolase	1	1	2	4	~	_	_	_	3	_	_	1
Ferritin, heavy polypeptide	3	~	~	1	2	_	_	_	_	_	_	_
Gastrotropin	1	2	1	~	2	_	_	_	_	_	_	_
*GDP-fucose transporter	~	~	~	~	~	1	_	_	_	_	_	_
Glycosyltransferase	~	~	1	1	1	_	_	_	_	_	_	_
Glutaminyl-tRNA synthase	1	~	1	~	~	_	_	_	_	_	_	_
*Hemoglobin cathodic alpha chain	2	~	2	~	~	_	_	_	_	_	_	_
Katanin	2	~	~	1	~	_	_	_	_	_	_	_
Lactate dehydrogenase	~	1	~	~	~	_	_	_	_	_	_	_
Lipase	2	1	3	~	1	1	1	_	_	_	_	_
*Maltase-glucoamylase	3	1	1	3	2	_	1	3	_	_	_	_
¥*Na.K-ATPase	1	2	~	1	1	_	_	_	_	_	_	_
*NADH dehydrogenase	1	2	~	~	1	1	_	_	_	_	_	_
Pyridine nucleotide-disulphide oxidoreductase	1	~	~	~	~	_	_	_	_	_	_	_
RAG1-activating protein 1 homolog	~	~	1	~	~	_	_	_	_	_	_	_
SH3 domain binding glutamic acid-rich-like protein	1	~	~	1	1	_	_	1	_	_	_	_
*Solute carrier 15	2	~	2	~	5	_	_	1	_	_	_	_
Triosephosphate isomerase	~	~	1	1	~	_	_	_	_	_	_	_
UGT1ab	~	~	~	~	~	1	_	_	_	_	_	_
Growth, differentiation, development	T0	BW	FW	MR	GRB	1	2	3	4	5	6	7
Actinin	1	~	~	~	~	_	_	_	_	_	_	_
Basic helix-loop-helix protein 2 (bHLHB2) Class B	~	~	~	1	~	_	_	_	_	_	_	_
Calpain	1	~	~	~	1	_	1	_	_	_	_	_
Caspase	1	~	~	~	~	_	_	_	_	_	_	_
*Cathepsin	2	~	~	2	1	_	_	2	_	_	_	_
CCAAT/enhancer binding	~	~	1	~	~	1	_	_	_	_	_	_
Chemotaxin (leucocyte cell derived)	2	16	2	~	22	6	20	_	_	_	_	_
¥*Claudin	5	1	3	3	6	3	_	3	_	_	_	_
*CUB and zona pellucida-like domain-containing protein 1	~	~	2	~	2	_	_	_	_	_	_	_
*Elongation factor 1-alpha	2	~	3	~	1	_	1	_	_	_	_	_
Ependymin precursor	~	~	~	~	~	1	_	_	_	_	_	_
Epithelial membrane protein	~	~	~	~	~	_	_	1	_	_	_	_
Galectin	3	~	2	5	~	_	_	_	_	_	_	_
GTPase slip-gc	~	~	~	~	~	1	_	_	_	_	_	_
Heart of glass protein	~	~	~	~	~	1	_	_	_	_	_	_
*Keratin	3	4	3	2	3	_	_	2	_	_	_	2
Neuronal guanine nucleotide exchange factor	~	~	1	~	~	_	_	_	_	_	_	_
*Nephrosin astacin-like metalloendopeptidase	1	~	~	~	~	_	_	_	_	_	_	_
*Profilin	1	2	~	1	1	_	3	1	_	_	_	_
¥S100 calcium binding protein	4	~	2	1	~	2	_	2	_	_	1	_
*Sciellin isoform a	~	~	~	~	1	1	_	_	_	_	_	_
Transcription factor INI	~	~	1	~	~	_	_	_	_	_	_	_
*Uroplakin 2	2	~	1	2	~	_	_	1	_	_	_	_
Zona pellucida glycoprotein	1	~	1	~	~	_	_	11	_	_	_	_
Membrane transporters and carrier proteins	T0	BW	FW	MR	GRB	1	2	3	4	5	6	7
Annexin	5	1	3	~	2	_	_	1	_	_	_	_
*Apolipoproteins	7	4	1	12	6	4	_	1	1	_	2	1
Cytolysin	~	~	~	~	~	_	_	4	_	_	_	_
Glutamyl aminopeptidase	~	~	~	~	~	1	_	_	_	_	_	_
Signal transduction	T0	BW	FW	MR	GRB	1	2	3	4	5	6	7
*Angiotensin	1	~	~	~	1	_	_	_	_	_	_	_
*Cytochrome P450	2	~	~	~	~	_	_	_	_	_	_	_
*Ictacalcin	~	~	~	~	~	_	_	4	_	_	_	_
¥*Inositol(myo)-1(or 4)-monophosphatase 1	~	1	~	1	1	1	_	_	_	_	_	_
*Interferon-induced gene 2	~	~	~	~	~	2	_	6	_	_	1	_
KDELR1	1	4	~	7	7	_	_	9	_	_	_	_
£Protein kinase C delta type	~	~	~	~	~	_	_	1	_	_	_	_
Myelin	~	~	~	~	~	_	_	2	_	_	_	_
*Prolactin	2	~	~	~	~	_	_	_	_	_	_	_
*Secretogranin III	1	~	~	~	~	_	_	_	_	_	_	_
Selenium binding protein 1	1	~	~	1	1	_	_	_	_	_	_	_
T-lymphocyte maturation-associated protein	2	~	~	~	2	_	_	_	_	_	_	_
Ubiquitin	1	~	~	~	~	_	_	_	_	_	_	_
*Zymogen granule	~	~	~	~	~	1	_	_	_	_	_	_
Structural/junctional complex	T0	BW	FW	MR	GRB	1	2	3	4	5	6	7
Actin alpha 1, skeletal muscle	1	~	~	~	~	_	_	_	_	_	_	_
Cofilin	2	~	1	2	~	2	_	3	_	_	_	_
*Collagen	1	~	2	~	1	1	_	_	_	_	_	_
High choriolytic enzyme 1 precursor	~	~	~	~	~	_	2	_	_	_	_	_
Mesothelin	1	~	~	~	~	1	_	_	_	_	_	_
Type i cytoskeletal protein	~	~	~	~	~	1	_	_	_	_	_	_
Transcription/translation	T0	BW	FW	MR	GRB	1	2	3	4	5	6	7
Neurogenic differentiation factor 1	~	~	~	~	1	_	_	_	_	_	_	_
Polymerase	1	~	~	~	~	_	_	_	_	_	_	_
PHD finger-like	~	~	~	~	~	1	_	_	_	_	_	_
RNA-binding protein	~	~	~	~	~	1	_	_	_	_	_	_
*Ribosomal protein	26	7	27	8	17	8	7	10	_	_	1	_
Translation initiation factor	1	~	~	~	~	1	_	_	_	_	_	_

*Indicates homologs identified in the study of Kalujnaia et al. [48], ^¥indicate those identified in Whitehead et al. (2011) and ^£those identified in Hoffman et al. [48].