Table 1.
Condition/disease | Subject | Source of conditioned medium | Outcome | Reference number |
---|---|---|---|---|
Alopecia—ID | Human | Hu-AD-MSC | Increased hair growth | [3] |
| ||||
Bald—SC | C3H/HeN nude mice | Hu-AD-SC | Hair growth | [5] |
| ||||
Acute hind limb ischemia—direct IM | Female athymic mouse | Hu-AD-SC | Decreased LL and F Increased BF, angiogenesis, endothelial growth, homing, and AA |
[6] |
SCID mice | Hu-ESC—endothelial cells | Vascularization and BF: CM restored defective diabetic PB derived PAC | [7] | |
| ||||
Chronic hind limb ischemia—7–10 days IM | Male nude athymic | Hu-PB-MNC-EPC Hu-UC-HUVEC |
Increased hind limb BF | [8] |
Male NOD-SCID mouse | Hu-AF—SC—Ckit (+) | Increased arteriogenesis, capillary density, total perfusion area, and mobility, and decreased muscular deg | [9] | |
| ||||
Skin wound direct—ID, [11] SC [10, 12]/topical application [4, 13] | Human | Hu-AD-SC | Enhanced wound healing Reduced adverse effects |
[4] |
BALBc nude mice | (i) Hu-UCB-MNC ⟶ UCB-SC (endothelial + MSC) (ii) HUVEC |
Faster wound healing: UCB-SC was better than HUVEC |
[10] | |
Diabetic immunodeficient mice | Hu-UCB-CD34-EPC | Faster wound closure Less granulation tissue area More neovascularization |
[11] | |
Male db/db (diabetic) mice | Hu-UC-MSC | Faster wound closure Increased capillary density |
[12] | |
BALBc-nude mouse | (i) Hu-ESC—derived EPC (ii) Hu-UCB-EPC |
Faster wound healing, granulation, and reepithelization: huESC-EPC was better than UCB-EPC | [13] | |
| ||||
Skin wound—48 hour after wound—SC | Male NOD-SCID mice | Hu-BM-MSC | Faster wound healing | [14] |
| ||||
MCI—direct—peri-infarct injection | Male SCID or C57BL/6 mouse | Hu-AD-SC | Improved cardiac function Reduced infarct size Effect of huAD-SC > CM |
[1] |
| ||||
MCI—end of 2nd hour R—IC | Female L pig | Porcine PB-EPC | Reduced IZ-A and infarct size Increased IZ angiogenesis IZ cardiomyocyte hypertrophy Improved LV contractility and relaxation |
[15] |
| ||||
MCI—4 hours—IV (jugular vein) | DL pig | Hu-ESC-MSC | Increased capillary density Reduced infarct size Preserved S-D performance |
[16] |
| ||||
MCI—48 hours-IM yo | Rat nude athymic | Hu-BM-derived MPC | Improved LV function Reduced LV dilation, myocyte A, and fibrosis Increased neovascularization |
[17] |
| ||||
MCI—5 min before R—IV, -at R—IC | Female DL pig | Hu-ESC derived MSC | (i) Reduced infarct size and A (ii) Improved S-D performance |
[18] |
| ||||
MCI—5 min before R—IV—(tail) | Mouse | Hu-ESC derived MSC | Reduced infarct size (>1000 kD/100–220 nm) = 10–220 nm < 10–100 nm |
|
| ||||
RSLT—direct—IV—(penile) | Male SD rat | Rat BM-MSC | Reduced LIB and PIC Increased survival |
[19] |
| ||||
Acute hepatic failure—24 hours—intrahepatic (left liver lobe) | CCl4 injured SCID/NOD mice | 1-Hu-AF MSC 2-AF-MSC-hepatic progenitor-like cells (HPL) |
(i) AST, ALT decreased (ii) Liver phenotype improvement HPL was better than MSC-CM |
[20] |
| ||||
Fulminant hepatic failure—24 hours—IV (penile) | Male SD rat | Hu-MSC | Reduced ALT, AST, TNFα, IL6, and IL1-rec-A level, and HP, ICI, and A Increased IL10 level, liver regeneration, and survival |
[21] |
Male SD rat | Hu-BM-MSC | Reduced panlobular leucocyte infiltrate, hepatocellular death, and bile duct duplication and increased survival | [22] | |
| ||||
Focal cerebral ischemia—72 hours—intranasal | Male SD rat | (i) Hu-SC-EDT (ii) BM-MSC (Lonza) |
Increased migration-diff—endogenous NPC, vasculogenesis, and motor function, and reduced infarct size (Hu SC-EDT = BM-MSC) |
[23] |
| ||||
Ischemic stroke—after 8 days—lateral ventricle infusion | Male SD mice | Hu-AD-MSC | Motor function maintained, reduced infarct volume, neural cell A, and astrogliosis, and increased microvessel | [24] |
| ||||
Cerebral ischemia infarction—1 day—IC/intracardiac (LV) injection | immunodeficient mice | (i) Hu-BM-MSC (ii) Hu-BM-CD133 (iii) Hu-BM-p75 (iv) Hu-fibro |
Reduced cortical infarct volume (huBM-CD133-CM < huBM-MSC-CM < hufibroCM < huBM-p75CM) |
[25] |
| ||||
Fluid percussion-TBI—direct IV jugular vein | Male SD rat | Hu-BM-MSC | Reduced neuron loss, A, neuron A, infarction volume, and motor deficit Increased VEGF(+) cells |
[26] |
| ||||
Fluid percussion TBI—12 hours after—IV | Male SD rat | Hu-BM-MSC | Decreased brain damage volume, brain damage incidence, and neuron A (hypoxia < normoxia) Increased motor/cognitive function and neurogenesis (hypoxia > normoxia) |
[27] |
| ||||
Contusion spinal cord injury—direct | Female Wistar rat | Rat-BM-MSC | Increased motor recovery | [28] |
| ||||
Chronic kidney disease—week 5—IV (tail) | Male Le rat | Hu embryonic MSC—stable—80 population doublings | Decreased systolic BP, proteinuria, and tubular + glomerular damage Increased inulin and PAH clearance, glomerular endothelium, and DNA repair |
[29] |
| ||||
Nephropathy—24 hours—IV (tail) | Mouse BALBc | (i) Hu-UCB-USSC (ii) Mouse BM-MSC |
No improvement in serum urea and creatinine, HP, and physical activity score | [30] |
| ||||
Normal—cancer cell line + CM xenograft | BALB mice | Hu-MSC (cell line) | Increased tumor cell proliferation (PCNA) and vascularization | [31] |
| ||||
VILI—before induction—IV—(tail) | Male C57BL/6 mouse | Mouse-iPSC | Reduced tidal volume, and bronchial microstructure restored | [32] |
| ||||
Intrabony periodontal defect direct—implant | Hybrid dog | Hu-MSC (Lonza) | Increased alveolar bone and cementum regeneration | [33] |
ID: intradermal, IM: intramuscular, SC: subcutaneous, MCI: myocardial infarct, R: reperfusion, IC: intracoronary artery, IV: intravenous, Imyo: intramyocardial, LV: left ventricular, RSLT: 50% reduced size liver transplantation, TBI: traumatic brain injury, VILI: ventilator induced lung injury, SCID: severe combined immunodeficient, NOD: nonobese diabetic, SD: Sprague-Dawley, DL: Dalland Landrace, L: Landrace, W: Wistar, Le: Lewis, hu: human, AD: adipose tissue derived, MSC: mesenchymal stem cells, SC: stem cell, ESC: embryonic stem cell, PB: peripheral blood, MNC: mononuclear cell, UC: umbilical cord, UCB: UC blood, BM: bone marrow, EPC: endothelial progenitor cell, HUVEC: human umbilical vein endothelial cell, AF: amniotic fluid, EDT: exfoliated deciduous tooth, MPC: mesenchymal progenitor cell, USSC: unrestricted somatic stem cell, iPSC: induced pluripotent stem cell, LL: limb lost, F: fibrosis, BF: blood flow, AA: antiapoptosis, CM: conditioned medium, PAC: proangiogenic cells, deg: degeneration, IZ: infarct zone, A: apoptosis, ALT: alanine amino transferase, AST: aspartate aminotransferase, HP: histopathology, ICI: immune cell infiltration, S-D: systolic-diastolic, LIB: liver injury biomarker, PIC: proinflammatory cytokine, Hu-SC-, IL1-rec-A: IL1 receptor antagonist, NPC: neural progenitor cell, PAH: para amino hippuric acid.