Table 1.
Average noncompartmental pharmacokinetic parameters of baclofen obtained after oral administration of baclofen (1 mg/kg) to each pretreated group. Distilled water (control) or each herbal medicine, that is, Oyaksungisan (OY) or Achyranthes bidentata radix (AB) extract, was administered orally for 7 consecutive days. On the final day, baclofen was administered orally after 10 min of the distilled water or each herbal medicine.
| Parameters | Control (n = 6) | OY (n = 4) | AB extract (n = 5) |
|---|---|---|---|
| t 1/2 (hr) | 4.10 ± 2.52 | 3.42 ± 0.74 | 3.64 ± 1.33 |
| T max (hr) | 0.67 ± 0.26 | 1.25 ± 0.50* | 0.45 ± 0.11 |
| C max (ng/mL) | 744.00 ± 252.96 | 441.50 ± 63.30* | 831.80 ± 53.00 |
| AUCall (ng·hr/mL) | 2042.33 ± 247.68 | 1899.00 ± 167.91 | 2144.54 ± 231.19 |
| AUCinf (ng·hr/mL) | 2051.75 ± 259.74 | 1905.79 ± 168.62 | 2152.10 ± 233.63 |
| V z/F (L/kg) | 2.78 ± 1.32 | 2.60 ± 0.54 | 2.41 ± 0.83 |
| CL/F (mL/min/kg) | 8.23 ± 1.06 | 8.80 ± 0.78 | 7.82 ± 0.85 |
| F e,urine (%) | 62.40 ± 8.56 | 61.08 ± 5.02 | 61.31 ± 14.25 |
| F (%) | 88.02 ± 11.14 | 81.76 ± 7.23 | 92.33 ± 10.02 |
* P < 0.05 versus control.