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. 2014 Jun 24;16(3):R67. doi: 10.1186/bcr3682

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Copyright © 2014 Vazquez-Ortiz et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Synergistic effect of lestaurtinib with AG14361 on inhibiting breast cancer tumors in allografts. Tumor progression (A-D) and body weight of recipient mice (E,F) and all experimental mice. (C,D) show tumor progression in four mice with complete tumor regression upon the combined treatment of lestaurtinib and AG14361 (indicated as Les + AG* in panels A and B). The day of implantation was designated as day 0 and the drug or vehicle was administered intraperitoneally to nude mice that had developed 92 J-wtBRCA1 and 92 J-shBRCA1 xenograft tumors of 50- to 100-mm³ volume (about 14 days after cell implantation). shBRCA1, sample with short hairpin RNA (shRNA) against breast cancer type 1 susceptibility (BRCA1); wtBRCA1, sample with wild-type BRCA1 status.