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. 2014 Jun 24;16(3):R67. doi: 10.1186/bcr3682

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Copyright © 2014 Vazquez-Ortiz et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Analysis of tumors treated with AG14361 and lestaurtinib as mono-treatment and combination therapy. Images (A) and quantification (B) of TUNEL assay for xenograft tumors from 92 J-shBRCA1 and 92 J-wtBRCA1 cell lines. (C, D) Images (C) and quantification (D) of PCNA immunochemical staining for the same tumors used in (A, B). Data show the mean of three different readings and are marked by columns with ± standard deviation (SD) error bars. PCNA, proliferating cell nuclear antigen; shBRCA1, sample with short hairpin RNA (shRNA) against breast cancer type 1 susceptibility (BRCA1); TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling; wtBRCA1, sample with wild-type BRCA1 status.