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. 2014 Jun 25;16(3):R134. doi: 10.1186/ar4591

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Copyright © 2014 Furman et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The effect of local intra-articular and systemic administration of IL-1 receptor antagonist (IL-1Ra) and soluble TNF receptor II (sTNFRII) on bone morphology of the tibial plateau following articular fracture. (A) Bone fraction and (B) bone density of the fractured limb as normalized to the contralateral control limb of each mouse for the tibial. Data presented as mean ± standard deviation (*difference between paired limbs is significantly different to zero, ^#significant difference between means in treatment groups). Representative axial micro computed tomography (microCT) images of the tibial plateau following (C) local intra-articular and (D) systemic administration of IL-1Ra and sTNFRII at 8 weeks following articular fracture. Bar, 1 mm.