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Synovial fluid levels of Cartilage oligomeric matrix protein (COMP) were elevated with fracture. Synovial fluid levels following fracture for contralateral control and fractured limbs with (A) Local intra-articular (IA) and (B) systemic administration of saline, IL-1 receptor antagonist (IL-1Ra) and soluble TNF receptor II (sTNFRII) (*significant difference between limbs).
