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Exemplar data for tissue oxygenation index (TOI) and hemoglobin content during walking. Changes in brain metabolic activity in response to walking are indicated by altered TOI (black solid line), oxygenated hemoglobin (O2Hb; gray solid line), and deoxygenated hemoglobin (HHb, gray dashed line). The participant is standing still for a short period of time at the start of the trial and then walks at steady state preferred speed until nearly the end of the trial.
