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. Author manuscript; available in PMC: 2014 Nov 13.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Jul 6;(7):CD001800. doi: 10.1002/14651858.CD001800.pub2
Methods Prospecitve, single centre RCT in the US. F/U 6 months.
Participants N= 88 (EX n=41; CON n=47)
100% male
Mean age: EX= 62 +/−8, CON = 63 +/−7; (range 42 - 72)
Diagnosis: CAD and a physical disability
Ethnicity: NR
Inclusion: ≤73 years; CAD and physical disability. CAD documented by history of MI, coronary artery bypass surgery, percutaneous transluminal coronary angioplasty or angiographically demonstrated CAD; have the functional use ofmore than 2 extremities, 1 being an arm, in order to perform the exercise test and training protocols
Exclusion: uncontrolled hypertension or diabetes mellitus, clinically significant cardiac dysrhythmias, unstable angina pectoris, cognitive deficits, or other problems that would interfere with compliance to the prescribed exercise and diet protocol
Interventions Exercise group (Home exercise training programme): Duration: 6 months; Frequency: 5 days/week; Session duration: 20mins/day; Intensity: 85% of predicted maximal heart rate Mode: stationary wheelchair ergometer
Control group: routine care
Outcomes Total mortality, non fatal MI at 6 months
Notes The treatment programme decreased myocardial oxygen demand.
Risk of bias
Bias Authors’ judgement Support for judgement
Random sequence generation (selection bias) Unclear risk “randomized”
Allocation concealment (selection bias) Unclear risk Not reported.
Blinding (performance bias and detection bias)
All outcomes
Low risk “The same experienced cardiologist interpreted all echocardiograms and was unaware of randomization procedures”
Incomplete outcome data (attrition bias)
All outcomes
High risk 32% lost to follow up, no description of withdrawals or dropouts
Selective reporting (reporting bias) Unclear risk No information reported.