Methods	RCT, single centre in Italy 33 (SD 7) months
Participants	N Randomised: Total:118 (99 males, 19 females); EX: 59 (49 males, 10 females) UC: 59 (50 males, 9 females) Diagnosis (% of pts); Myocardial Infarction: EX 51; UC 47 Hypercholesterolemia: EX 61; UC 54 Diabetes: EX 17; UC 20 Hypertension: EX 42; UC 47 LVEF (%): EX 52 (SD 16); UC 50 (SD 14) Case mix: Age (years): EX: 53 (SD 11); UC: 59 (SD 10) Percentage male: EX 83.1%; UC 84.8% Percentage white: Not reported Inclusion/exclusion criteria: Inclusion: successful procedure of coronary angioplasty in 1 or 2 native epicardial coronary arteries and ability to exercise Exclusion: previous coronary artery procedures, cardiogenic shock, unsuccessful angioplasty (defined as residual stenosis>30% of initial value), complex ventricular arrhythmias, uncontrolled hypertension and diabetes mellitus, creatinine ?2.5 mg/dl, orthopedic or neurological limitations to exercise or unstable angina after procedure and before enrolment
Interventions	Exercise: Total duration: six months aerobic/resistance/mix: exercise sessions were performedat the hospital gym and were supervised by a cardiologist frequency: 3 sessions/week duration: 15 min of stretching and callisthenics; 5 min of loadless warm-up; 30 min of pedaling on electronically braked cycle ergometer at target work rate; 3 min of unloaded cool-down pedaling intensity: 60% of peak oxygen uptake (VO2) modality: electronically braked cycle ergometer Usual care: “Control patients were recommended to perform basic daily mild physical activities but to avoid any physical training.”
Outcomes	Cardiac mortality; myocardial infarction; coronary angioplasty (percutaneous translu-minal coronary angioplasty, coronary stent); coronary artery bypass graft; health-related quality of life: MOS Short-Form General Health Survey
Notes
Risk of bias
Bias	Authors’ judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported.
Allocation concealment (selection bias)	Unclear risk	Not reported.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	“All studies were performed by experienced operators and evaluated by two independent observers blinded to treatment arm and to each otherls interpretation. ” Comment: This only applied to exercise test & angiography only so assessment of events and health-related quality of life (although patient self complete) not necessarily blinded
Incomplete outcome data (attrition bias) All outcomes	High risk	Cardiac events of 12 patients who were excluded not accounted for
Selective reporting (reporting bias)	Unclear risk	No information reported.