Methods | Participants randomised after routine angiography for angina. 66% study population had previous MI. All participants spent one week as inpatient on a metabolic ward receiving instruction on exercise and diet |
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Participants | 113 men with CAD, aged 35 - 68 yrs (mean 53.5) | |
Interventions | 2 further weeks as IP, then daily exercise at home on cycle (30 mins at 75% HR max) + 2 group training sessions of 60 mins/week. Informative session held 5 times/year for participants and spouses. F/U yearly for 6 years. |
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Outcomes | Total and CHD mortality, non fatal MI, revascularisation, | |
Notes | Exercise adherence in the first year was 68% (39-92%, over the next 5 years 33% (389%). Pts with regression of coronary atheroma attended exercise sessions significantly more often (54+/− 24%) than patients with no change (20+/− 24%) or progression 31+/− 20%) |
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Risk of bias | ||
Bias | Authors’ judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not reported. |
Allocation concealment (selection bias) | Low risk | “sealed envelopes” |
Blinding (performance bias and detection bias) All outcomes |
Unclear risk | Unclear in terms of assessment of outcomes. |
Incomplete outcome data (attrition bias) All outcomes |
High risk | 20% lost to follow up, no description of withdrawals or dropouts |
Selective reporting (reporting bias) | Unclear risk | No information reported. |