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. Author manuscript; available in PMC: 2014 Nov 13.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Jul 6;(7):CD001800. doi: 10.1002/14651858.CD001800.pub2
Methods Single centre RCT in Japan; F/U months
Participants N= 39 (EX n=20; CON n=19)
100% male
Mean age: 69.5 years
Diagnosis: stable CAD
Ethnicity: Japanese patients
Inclusion: <65 years old with stable CAD
Exclusion:ongoing congestive heart failure, liver dysfunction, renal dysfunction, or systemic diseases, including malignancy and collagen disease
Interventions EX:exercise training Duration 6 months; Frequency: weekly; Session duration and mode: 20-60min upright aerobic and dynamic exercise (walking, bicycling, jogging etc) and light isometric exercise (hand weights) and 15 min cool-down stretching and callisthenics. Intensity: prescribed individually at the anaerobic threshold level as measured by a treadmill exercise test. Patients also encouraged to perform aerobic exercise twice weekly (≥30 min) at home. Co-intervention: diet therapy, and weekly counselling
Control: usual outpatient care
Outcomes Total mortality; non-fatal/fatal mortality. See notes below.
Notes “No subject in either group showed any worsening of symptoms or had clinical events during this study.”
Risk of bias
Bias Authors’ judgement Support for judgement
Random sequence generation (selection bias) Unclear risk “randomly assigned”
Allocation concealment (selection bias) Unclear risk Not reported.
Blinding (performance bias and detection bias)
All outcomes
Unclear risk Unclear in terms of assessment of outcomes.
Incomplete outcome data (attrition bias)
All outcomes
Unclear risk No information reported.
Selective reporting (reporting bias) Unclear risk No information reported.