Methods | Single centre RCT in Japan; F/U months | |
Participants | N= 39 (EX n=20; CON n=19) 100% male Mean age: 69.5 years Diagnosis: stable CAD Ethnicity: Japanese patients Inclusion: <65 years old with stable CAD Exclusion:ongoing congestive heart failure, liver dysfunction, renal dysfunction, or systemic diseases, including malignancy and collagen disease |
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Interventions | EX:exercise training Duration 6 months; Frequency: weekly; Session duration and mode: 20-60min upright aerobic and dynamic exercise (walking, bicycling, jogging etc) and light isometric exercise (hand weights) and 15 min cool-down stretching and callisthenics. Intensity: prescribed individually at the anaerobic threshold level as measured by a treadmill exercise test. Patients also encouraged to perform aerobic exercise twice weekly (≥30 min) at home. Co-intervention: diet therapy, and weekly counselling Control: usual outpatient care |
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Outcomes | Total mortality; non-fatal/fatal mortality. See notes below. | |
Notes | “No subject in either group showed any worsening of symptoms or had clinical events during this study.” | |
Risk of bias | ||
Bias | Authors’ judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | “randomly assigned” |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding (performance bias and detection bias) All outcomes |
Unclear risk | Unclear in terms of assessment of outcomes. |
Incomplete outcome data (attrition bias) All outcomes |
Unclear risk | No information reported. |
Selective reporting (reporting bias) | Unclear risk | No information reported. |