Methods | Participants treated at one of 5 participating centres. Participants randomised after participating in low level exercise course for 6 weeks | |
Participants | 651 men aged 30 - 64 yrs with MI between 8 weeks and 3 years prior to start of study (mean 14 months). Mean age I = 51.5+/− 7.4, C= 52.1 +/− 7.2 |
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Interventions | ET- 1 hour/day, 3 days/week for 8 weeks. 6 station circuit + gym exercises or swimming and games. F/U 3 years. Long term follow up to 19 years published in 1999, but not used for meta analysis |
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Outcomes | Total & CHD mortality, non fatal MI | |
Notes | 90% of ET attended 90% of 24 scheduled sessions post randomisation, only 48% attending > 50% of sessions at 18 months. 30% of control alleged exercising regularly, on own initiative. At 19 years any protective effect form the programme had decreased over time, but an increase with PWC from the beginning to the end of the trial was associates with a consistent reduction in mortality throughout the 19 years of follow up |
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Risk of bias | ||
Bias | Authors’ judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | “randomized” |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding (performance bias and detection bias) All outcomes |
Unclear risk | Unclear in terms of assessment of outcomes. |
Incomplete outcome data (attrition bias) All outcomes |
High risk | 6.5% lost to follow up, no description of withdrawals or dropouts |
Selective reporting (reporting bias) | Unclear risk | No information reported. |