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. Author manuscript; available in PMC: 2014 Nov 13.
Published in final edited form as: Cochrane Database Syst Rev. 2011 Jul 6;(7):CD001800. doi: 10.1002/14651858.CD001800.pub2
Methods Participants treated at one of 5 participating centres. Participants randomised after participating in low level exercise course for 6 weeks
Participants 651 men aged 30 - 64 yrs with MI between 8 weeks and 3 years prior to start of study (mean 14 months).
Mean age
I = 51.5+/− 7.4,
C= 52.1 +/− 7.2
Interventions ET- 1 hour/day, 3 days/week for 8 weeks. 6 station circuit + gym exercises or swimming and games.
F/U 3 years.
Long term follow up to 19 years published in 1999, but not used for meta analysis
Outcomes Total & CHD mortality, non fatal MI
Notes 90% of ET attended 90% of 24 scheduled sessions post randomisation, only 48% attending > 50% of sessions at 18 months.
30% of control alleged exercising regularly, on own initiative.
At 19 years any protective effect form the programme had decreased over time, but an increase with PWC from the beginning to the end of the trial was associates with a consistent reduction in mortality throughout the 19 years of follow up
Risk of bias
Bias Authors’ judgement Support for judgement
Random sequence generation (selection bias) Unclear risk “randomized”
Allocation concealment (selection bias) Unclear risk Not reported.
Blinding (performance bias and detection bias)
All outcomes
Unclear risk Unclear in terms of assessment of outcomes.
Incomplete outcome data (attrition bias)
All outcomes
High risk 6.5% lost to follow up, no description of withdrawals or dropouts
Selective reporting (reporting bias) Unclear risk No information reported.