Trial name or title	The Understanding Prognostic Benefits of Exercise and Antidepressant Therapy for Persons with Depression and Heart Disease (UPBEAT) Study
Methods	5-year, single-site randomised clinical trial sponsored by the National Heart, Lung, and Blood Institute
Participants	200 clinically depressed patients (with scores of Beck Depression Inventory ≥9) with stable CHD, including a previous (>60 days) myocardial infarction, revascularisation procedure, such as a PTCA or CABG, or a cardiac catheterization demonstrating significant coronary artery stenosis
Interventions	4 months of treatment with supervised aerobic exercise, sertraline, or placebo
Outcomes	Depressive symptoms, heart rate variability, baroreflex control, vascular function (i.e., flow-mediated dilation), measures of inflammation and platelet aggregation
Starting date	Not reported.
Contact information	Blume003@mc.duke.edu
Notes	“This study is not powered to assess treatment group differences in CHD morbidity and mortality.”