Table 4.
Adjusted mean (±SE) scores of K-mMMSE and cognitive domains according to categories of UACR in APOE E4 carriers.
| K-mMMSE and cognitive domain scores according to UACR (mg/g) | P for overall | P for linear | Partial eta-squared, % | ||||
|---|---|---|---|---|---|---|---|
| <15.0 | 15.0–29.9 | 30.0–299.9 | ≥300.0 | difference | trend | ||
| Number | 852 | 402 | 421 | 23 | |||
| Global | |||||||
| K-mMMSE (100) | 78.2 ± 0.4 | 75.3 ± 0.6 | 77.0 ± 0.6 | 70.0 ± 2.6 | <0.001 | 0.007 | 1.6 |
| Domains | |||||||
| Attention (7) | 3.6 ± 0.1 | 3.5 ± 0.1 | 3.7 ± 0.1 | 3.0 ± 0.4 | 0.236 | 0.891 | 0.3 |
| Memory (26) | 21.2 ± 0.2 | 19.5 ± 0.2 | 20.5 ± 0.2 | 19.4 ± 1.0 | <0.001 | 0.003 | 2.2 |
| Orientation (20) | 18.6 ± 0.1 | 18.2 ± 0.2 | 18.2 ± 0.2 | 16.3 ± 0.7 | 0.002 | 0.003 | 1.1 |
| Visuospatial (10) | 8.1 ± 0.1 | 7.8 ± 0.1 | 8.2 ± 0.1 | 7.3 ± 0.5 | 0.022 | 0.823 | 0.7 |
| Language (18) | 15.1 ± 0.1 | 15.0 ± 0.1 | 14.9 ± 0.1 | 13.4 ± 0.6 | 0.029 | 0.079 | 0.7 |
| Frontoexecutive (19) | 11.8 ± 0.1 | 11.5 ± 0.2 | 11.5 ± 0.2 | 10.2 ± 0.7 | 0.107 | 0.083 | 0.5 |
Data are expressed as mean ± standard error. The numbers in the brackets following domain names represent the total (maximum) score.
Adjusted for age, sex, educational attainments, smoking status, alcohol use, BMI, eGFR, hypertension, type 2 diabetes, hyperlipidemia, and CES-DK.