Table 2.
Meta-analysis assessing the association between IGF1R expression and clinical characteristics
| Clinical characteristics | No. of Studies | Cases | Pooled Data | Test for Heterogeneity | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| OR | 95% CI | P-value | Chi2 | P-value | I2 (%) | |||
| Gender (male/female) | 15 | 2554 | 1.19 | 0.98-1.43 | 0.08 | 16.49 | 0.28 | 15 |
| Smoking (ever/none) | 13 | 2169 | 1.45 | 1.13-1.85 | 0.003 | 22.39 | 0.03 | 46 |
| Age (< 60/≥ 60) | 3 | 397 | 1.15 | 0.47-2.81 | 0.75 | 5.43 | 0.07 | 63 |
| Tumor size (T1, 2/T3, 4) | 4 | 640 | 0.61 | 0.60-0.95 | 0.03 | 1.62 | 0.66 | 0 |
| Histological Type (SCC/ADC) | 10 | 1527 | 2.08 | 0.88-4.93 | 0.09 | 80.00 | < 0.00001 | 89 |
| Differentiation (poor/well-moderate) | 9 | 1585 | 1.04 | 0.66-1.63 | 0.87 | 23.09 | 0.003 | 65 |
| TNM Stage (INM Sta) | 7 | 1596 | 0.93 | 0.65-1.33 | 0.71 | 13.17 | 0.04 | 54 |
| Lymph Node Metastasis (NX/N0) | 6 | 1185 | 1.31 | 0.85-2.02 | 0.22 | 12.54 | 0.03 | 60 |
Abbreviation: No., number; SCC, Squamous cell carcinoma; ADC, Adenocarcinoma.