Figure 3.
MiR-634 inhibits tumor growth and sensitizes nasopharyngeal carcinoma cells to paclitaxel in vivo. BALB/C nude mice were subcutaneously inoculated with CNE-1/Taxol cells with overexpressed miR-634 (Lv-miR-634, n = 5) and negative controls (Lv-miR-NC, n = 5), respectively. After 61 days, paclitaxel (10 mg kg-1) was then intravenously injected into mice once a day for five days. A. Tumor volume (mm3) was calculated every 4 days. B. Two days after complete paclitaxel treatments, all mice were euthanized and the tumors were excised and imaged under a light microscope. C. qRT-PCR analysis showed that miR-634 was upregulated in transplanted tumour tissues inoculated by miR-634-overexpressing CNE-1/Taxol cells. *P < 0.05.