Table 2.
Comparison of OPN promoter between ICC patients and healthy controls
| controls | Patients | ICC | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||
| n | n | P | LN (+) | LN (-) | P | DM (-) | DM (+) | P | |
| -66 T/G | |||||||||
| TT | 251 | 256 | 1.00 | 158 | 99 | 1.00 | 228 | 28 | 1 |
| TG | 9 | 4 | 0.261 | 2 | 1 | 0.637 | 3 | 1 | 0.537 |
| -156 | |||||||||
| G/G | 107 | 111 | 1.00 | 53 | 35 | 1.00 | 101 | 13 | 1 |
| G/GG | 110 | 101 | 0.563 | 74 | 45 | 0.775 | 92 | 10 | 0.826 |
| GG/GG | 43 | 48 | 0.804 | 33 | 20 | 0.860 | 38 | 6 | 0.786 |
| -443 | |||||||||
| TT | 114 | 120 | 1 | 49 | 47 | 1.00 | 111 | 8 | 1.000 |
| CT | 115 | 111 | 0.709 | 63 | 38 | 0.116 | 102 | 9 | 0.803 |
| CC | 31 | 29 | 0.773 | 48 | 15 | 0.002 | 17 | 12 | < 0.001 |
Note: LN: Lymph node metastasis; P value was calculated by chi-square test and a Fisher’s exact test. DM: distant metastasis.