Table 4.
Correlations between the expression of CD4, CD20, CD68 and FOXp3 in meningioma and clinicopathologic parameters in 93 patients
| Parameter | CD4+ | P value | CD20+ | P value | CD68+ | P value | Foxp3+ | P value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|||||||||
| Low Group | High Group | Low Group | High Group | Low Group | High Group | Low Group | High Group | |||||
| Age, y | ||||||||||||
| <60 | 61 | 14 | 0.592 | 68 | 7 | 0.632 | 40 | 35 | 0.128 | 22 | 53 | 0.073 |
| ≥60 | 13 | 5 | 15 | 3 | 6 | 12 | 1 | 17 | ||||
| Recurrence | ||||||||||||
| No | 78 | 9 | 0.147 | 84 | 3 | 0.003 | 59 | 28 | 0.654 | 40 | 47 | 0.33 |
| Yes | 4 | 2 | 3 | 3 | 3 | 3 | 1 | 5 | ||||
| Sex | ||||||||||||
| Male | 21 | 9 | 0.114 | 25 | 5 | 0.362 | 13 | 17 | 0.553 | 13 | 17 | 0.009 |
| Female | 53 | 10 | 58 | 5 | 33 | 30 | 10 | 53 | ||||
| Tumor size, cm | ||||||||||||
| ≥7 cm | 11 | 1 | 0.219 | 12 | 0 | 0.613 | 4 | 8 | 0.331 | 0 | 12 | 0.004 |
| ≥4.5-7 cm | 33 | 10 | 40 | 3 | 22 | 21 | 19 | 24 | ||||
| <4.5 cm | 34 | 4 | 35 | 3 | 22 | 16 | 8 | 30 | ||||
| Grade | ||||||||||||
| WHO Grade I | 69 | 20 | 0.574 | 80 | 9 | 1 | 51 | 38 | 0.854 | 26 | 63 | 0.481 |
| Transitional | 22 | 8 | 0.573 | 26 | 4 | 0.354 | 16 | 14 | 0.083 | 8 | 22 | 0.004 |
| Fibrous | 20 | 4 | 23 | 1 | 10 | 14 | 2 | 22 | ||||
| Meningothelial | 10 | 5 | 13 | 2 | 8 | 7 | 8 | 7 | ||||
| Psammomatous | 7 | 1 | 8 | 0 | 6 | 2 | 1 | 7 | ||||
| Angiomatous | 5 | 2 | 5 | 2 | 6 | 1 | 3 | 4 | ||||
| Secretory | 5 | 0 | 5 | 0 | 5 | 0 | 4 | 1 | ||||
| WHO grade II | ||||||||||||
| Atypical | 4 | 0 | 4 | 0 | 3 | 1 | 0 | 4 | ||||
NOTE: CD4, CD20, CD68 and FOXp3 cells were classified as high density and low density groups based on the independent histopathologic reviews of two pathologists. Data were analyzed by Pearson’s Chi-square test analysis.