Table 2.
Genotype distributions and allele frequencies of the 5 examined polymorphisms between the reduced and preserved LVEF groups in CAD patients and the risk prediction under various genetic models
| SNP ID (rs number) | Genotype and allele | Cases | Control | P Χ2 a | Genetic models | Unadjusted | Adjustedb | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
||||||||||
| OR | 95% CI | P value | OR | 95% CI | P value | ||||||
| rs5065 | GG | 0 | 0 | 0.75 | Allelic comparison | 0.81 | 0.22-2.97 | 0.75 | 0.84 | 0.23-3.11 | 0.80 |
| AG | 3 | 10 | Dominant model | 0.81 | 0.22-2.98 | 0.75 | 0.84 | 0.23-3.12 | 0.80 | ||
| AA | 198 | 535 | Recessive model | –c | – | – | – | – | – | ||
| G (%) | 0.7 | 0.9 | 0.75 | Homozygote comparison | – | – | – | – | – | – | |
| A (%) | 99.3 | 99.1 | Additive model | 0.81 | 0.22-2.98 | 0.75 | 0.84 | 0.23-3.12 | 0.80 | ||
| rs5063 | TT | 4 | 7 | 0.78 | Allelic comparison | 1.09 | 0.74-1.61 | 0.65 | 1.06 | 0.72-1.58 | 0.76 |
| CT | 32 | 86 | Dominant model | 1.06 | 0.69-1.62 | 0.79 | 1.04 | 0.67-1.60 | 0.87 | ||
| CC | 165 | 452 | Recessive model | 1.56 | 0.45-5.39 | 0.48 | 1.43 | 0.40-5.13 | 0.58 | ||
| T (%) | 10.0 | 9.2 | 0.65 | Homozygote comparison | 1.57 | 0.45-5.42 | 0.48 | 1.46 | 0.41-5.20 | 0.56 | |
| C (%) | 90.0 | 90.8 | Additive model | 1.09 | 0.75-1.58 | 0.66 | 1.06 | 0.72-1.55 | 0.77 | ||
| rs632793 | GG | 6 | 9 | 0.50 | Allelic comparison | 1.07 | 0.76-1.50 | 0.69 | 1.06 | 0.75-1.50 | 0.75 |
| AG | 42 | 120 | Dominant model | 1.01 | 0.69-1.48 | 0.95 | 1.02 | 0.69-1.50 | 0.93 | ||
| AA | 153 | 416 | Recessive model | 1.83 | 0.64-5.22 | 0.26 | 1.56 | 0.53-4.56 | 0.42 | ||
| G (%) | 13.4 | 12.7 | 0.69 | Homozygote comparison | 1.81 | 0.64-5.18 | 0.27 | 1.54 | 0.52-4.52 | 0.43 | |
| A (%) | 86.6 | 87.3 | Additive model | 1.07 | 0.77-1.49 | 0.70 | 1.06 | 0.75-1.48 | 0.75 | ||
| rs198388 | TT | 5 | 14 | 0.50 | Allelic comparison | 0.84 | 0.61-1.17 | 0.30 | 0.81 | 0.58-1.13 | 0.22 |
| CT | 45 | 145 | Dominant model | 0.8 | 0.56-1.16 | 0.25 | 0.78 | 0.53-1.14 | 0.20 | ||
| CC | 151 | 386 | Recessive model | 0.97 | 0.34-2.72 | 0.95 | 0.85 | 0.30-2.44 | 0.76 | ||
| T (%) | 13.7 | 15.9 | 0.30 | Homozygote comparison | 0.91 | 0.32-2.58 | 0.86 | 0.82 | 0.28-2.35 | 0.71 | |
| C (%) | 86.3 | 84.1 | Additive model | 0.84 | 0.61-1.17 | 0.30 | 0.81 | 0.59-1.13 | 0.22 | ||
| rs198389 | GG | 6 | 10 | 0.43 | Allelic comparison | 0.96 | 0.68-1.33 | 0.79 | 0.95 | 0.68-1.34 | 0.77 |
| AG | 42 | 132 | Dominant model | 0.89 | 0.61-1.29 | 0.54 | 0.89 | 0.61-1.31 | 0.56 | ||
| AA | 153 | 402 | Recessive model | 1.64 | 0.59-4.58 | 0.34 | 1.49 | 0.52-4.27 | 0.45 | ||
| G (%) | 13.4 | 14.0 | 0.79 | Homozygote comparison | 1.58 | 0.56-4.41 | 0.39 | 1.44 | 0.51-4.13 | 0.49 | |
| A (%) | 86.6 | 86.0 | Additive model | 0.96 | 0.69-1.33 | 0.79 | 0.95 | 0.68-1.33 | 0.77 | ||
a
P values were calculated by x2 test for differences in genotypes and alleles between the two groups.
b
ORs adjusted for age, gender, HTN, DM, HLP, Stroke history, smoking habit and angiographic profile.
c
data not available.