Table 1.
Compounds | IC50 ± SDs μM (fold-reverse) | |
|
||
A549 | A549/siAxl | |
| ||
Doxorubicin | 1.1004 ± 0.1022 | 0.7004 ± 0.0902 (1.57)* |
Vincristine | 0.0066 ± 0.0053 | 0.0018 ± 0.0012 (3.67)** |
Paclitaxel | 0.0017 ± 0.0134 | 0.0007 ± 0.0821 (2.43)** |
| ||
H460 | H460/siAxl | |
| ||
Doxorubicin | 12.0003 ± 1.0243 | 4.0124 ± 0.3002 (2.99)** |
Vincristine | 0.0014 ± 0.0091 | 0.0006 ± 0.0034 (2.33)** |
Paclitaxel | 0.0030 ± 0.0230 | 0.0011 ± 0.0149 (2.73)** |
Cell survival was determined by MTT assays as described in “Materials and Methods”. Data are the means ± SDs of at least three independent experiments.
P < 0.05, for values versus that obtained in the parent cells;
P < 0.01, for values versus that obtained in the parent cells.