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MiR-378 down regulates expression of apoptosis-related proteins through the activation of the PI3K/Akt pathway. (A) The expression of p-PI3K, p-Akt and (B) apoptosis proteins Cyt C, Apaf-1, and Bax detected by western blotting of protein samples from high glucose (25.5 mM) cultures of MC3T3-E1/miR-378 cells treated (+) or not treated (-) with PI3K inhibitor LY294002. β-actin was an internal control.
