Table 2.
Multivariate analyses of prognostic factors for OS in non-M3 AML
| All patients | NPM1wtFLT3-ITDwtpatients | |||
|---|---|---|---|---|
|
| ||||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex | 0.922 (0.56-1.497) | 0.743 | 0.891 (0.560-1.418) | 0.628 |
| Age | 1.938 (1.270-2.958) | 0.002 | 2.073 (1.326-3.242) | 0.001 |
| WBC | 1.555 (1.026-2.354) | 0.037 | 1.140 (0.723-1.797) | 0.573 |
| Karyotype risk | 1.979 (1.467-2.669) | < 0.001 | 1.953 (1.422-2.682) | <0.001 |
| dmCEBPA vs wtCEBPA | 0.596 (0.358-0.992) | 0.047 | 0.650 (0.431-0.980) | 0.040 |
| smCEBPA vs wtCEBPA | 0.869 (0.458-1.650) | 0.669 | 0.763 (0.387-1.503) | 0.434 |
| FLT3 | 0.606 (0.304-1.208) | 0.155 | - | - |
| NPM1 | 0.852 (0.338-2.145) | 0.734 | - | - |
| C-KIT | 0.906 (0.319-2.576) | 0.853 | 0.842 (0.296-2.398) | 0.748 |
| N/K-RAS | 1.695 (0.825-3.483) | 0.151 | 1.576 (0.797-3.116) | 0.191 |
| IDH1/2 | 1.354 (0.643-2.850) | 0.425 | 2.321 (1.037-5.197) | 0.041 |
| DNMT3A | 1.061 (0.417-2.698) | 0.901 | 1.848 (0.443-7.703) | 0.399 |
HR: hazard ratio; CI: confidence interval; -: not included.