Table 5.
Cox regression model analysis of overall survival (OS) in 173 colon cancer patients
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
|
|
|
|||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age | ||||
| < 65 y | 1 | |||
| ≥ 65 y | 1.212 (0.732, 2.006) | 0.455 | ||
| Gender | ||||
| Male | 1 | |||
| Female | 1.316 (0.794, 2.179) | 0.287 | ||
| Location | ||||
| Right | 1 | |||
| Transverse | 1.076 (0.413, 2.805) | 0.881 | ||
| Left | 1.011 (0.606, 1.687) | 0.967 | ||
| T stage | ||||
| T1 | 1 | |||
| T2 | 0.262 (0.037, 1.868) | 0.181 | ||
| T3 | 0.761 (0.174, 3.334) | 0.717 | ||
| T4 | 2.512 (0.609, 10.362) | 0.203 | ||
| N stage | ||||
| N0 | 1 | NR | ||
| N1 | 4.447 (2.278, 8.684) | < 0.001 | ||
| N2 | 16.131 (8.069, 32.245) | < 0.001 | ||
| M stage | ||||
| M0 | 1 | NR | ||
| M1 | 13.222 (7.068, 24.734) | < 0.001 | ||
| AJCC stage | ||||
| I | 1 | 1 | ||
| II | 1.548 (0.334, 7.176) | 0.576 | 1.133 (0.243, 5.276) | 0.874 |
| III | 8.786 (2.113, 36.530) | 0.003 | 5.183 (1.232, 21.803) | 0.025 |
| IV | 57.871 (12.843, 260.767) | < 0.001 | 15.843 (3.033, 82.751) | 0.001 |
| Differentiation | ||||
| Well | 1 | 1 | ||
| Moderate | 2.140 (1.153-3.975) | 0.016 | 1.174 (0.613, 2.247) | 0.628 |
| Poorly | 7.853 (4.142-14.889) | < 0.001 | 2.928 (1.331, 6.441) | 0.008 |
| Vessel invasion | ||||
| No | 1 | 1 | ||
| Yes | 3.926 (1.989, 7.752) | < 0.001 | 0.801 (0.359, 1.784) | 0.587 |
| eIF3e | ||||
| Negative | 1 | 1 | ||
| Weak | 6.979 (1.647, 29.573) | 0.008 | 4.940 (1.141, 21.379) | 0.033 |
| Strong | 40.933 (9.437, 177.537) | < 0.001 | 17.027 (3.744, 77.424) | < 0.001 |
HR, Hazard ratio; CI, confidence interval; NR, variable was not include in the resultant model; P < 0.05 indicated that the 95% CI of HR was not including 1.