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. 2014 Nov 13;5:389. doi: 10.3389/fgene.2014.00389

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Copyright © 2014 Schubert, Rudnik and Schubert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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~85 kb euchromatin segments may loop out from their CTs. (A) Scheme of chromosome 1 showing the labeling of CT1top arm, and BAC T2P11 therein in different color as used for FISH. (B) Examples of chromatin configurations in 4C, 32C, and 64C nuclei. Sister chromatid territories of one (asterisks) or both (cross) homologs may be separated due to missing chromosome arm cohesion. The T2P11 segment is associated with (triangle) or separated from its CT (arrows). The strongly elongated 4C nucleus shows the T2P11 segment absent from the left CT and moved into the homologous right CT.