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. 2014 Nov 13;5:389. doi: 10.3389/fgene.2014.00389

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Copyright © 2014 Schubert, Rudnik and Schubert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heterologous associations in cis and trans. (A) Schemes of chromosomes 1, 3, and 5 showing euchromatin segments (probed by BACs) containing high (connected by bold red lines) or low (bold green lines) co-expressing genes (encoded proteins in parentheses). The percentage of association in cis or trans in 2C and 4C nuclei is indicated (for number of nuclei analyzed see Table S3). The thin black lines indicate combinations with missing co-expression data. (B) Examples of 2C and 4C nuclei showing different configurations of euchromatic segments probes by BACS F28P5, T29H11, and F13K9. The segments may be associated (arrows) or separated. Compare 2C values with the simulated random values according to the RSD model for loci at different arms of the same chromosome (17.2%) and for loci located at different chromosomes (9.9%) (^*P < 0.05, ^**P < 0.01; ^***P < 0.001).