Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Nov 13;8:376. doi: 10.3389/fncel.2014.00376

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 Averaimo and Nicol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Spatiotemporal dynamics of cAMP during neuronal polarization and neurotransmitter specification. (A) Local interactions between cAMP and cGMP determine neurite maturation into axon or dendrite. High cAMP and low cGMP concentrations promote axonogenesis, whereas low cAMP and high cGMP lead to dentritogenesis. (B) In developing neurons, cAMP transients and calcium spikes are interdependent. The choice of expression of excitatory or an inhibitory neurotransmitter is modulated by the frequency of calcium spikes, which is regulated by the activity of a set of kinases including the cAMP effector PKA.