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. 2014 Nov 13;8:376. doi: 10.3389/fncel.2014.00376

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Copyright © 2014 Averaimo and Nicol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spatiotemporal dynamics of cAMP during developmental pruning of ectopic axonal branches, and synaptic competition. cAMP is required in two subcellular compartments during the synaptic refinement of neuronal projections. In the soma of retinal ganglion cells, cAMP oscillations and spontaneous calcium waves are interdependent. Spontaneous calcium waves are required for competition between axons in their targets. In the synapses, cAMP signaling mediated by adenylyl cyclases 1 and 8 is involved in synaptic potentiation and hebbian mechanisms, which are crucial to eliminate misplaced synapses.