Table 1.
Clinicopathological variables in 92 consecutive pancreatoduodenectomies for pancreatic cancer stratified by COX-2 status
| Characteristic | n(%) | COX2-neg. n(%) | COX2-pos. n(%) | p a |
|---|---|---|---|---|
| COX-2 |
|
|
|
|
| Positive |
65 (71%) |
|
|
|
| Negative |
27 (29%) |
|
|
|
| Tumour size |
|
|
|
|
| ≤ 20 mm |
15 (16%) |
3 (20%) |
12 (80%) |
|
| > 20 mm |
77 (84%) |
24 (31%) |
53 (69%) |
0.54b |
| Lymph node metastasis |
|
|
|
|
| N0, n (%) |
25 (27%) |
5 (20%) |
20 (80%) |
|
| N1, n (%) |
67 (73%) |
22 (33%) |
45 (67%) |
0.229 |
| Lymph node ratio (LNR)c |
|
|
|
|
| ≤ 0.2 |
54 (59%) |
13 (24%) |
41 (76%) |
|
| > 0.2 |
37 (41%) |
13 (36%) |
24 (65%) |
0.251 |
| Vascular invasion |
|
|
|
|
| No, n (%) |
30 (33%) |
12 (40%) |
18(60%) |
|
| Yes, n (%) |
62 (67%) |
15 (24%) |
47 (76%) |
0.119 |
| Perineural infiltration |
|
|
|
|
| No, n (%) |
15 (16%) |
3 (20%) |
12 (80%) |
|
| Yes, n (%) |
77 (84%) |
24 (31%) |
53 (69%) |
0.54b |
| T classification |
|
|
|
|
| T1 |
3 (3%) |
1 (33%) |
2 (67%) |
|
| T2 |
6 (7%) |
1 (17%) |
5 (83%) |
|
| T3 |
83 (90%) |
25 (30%) |
58 (70%) |
0.851b |
| R1 resection status, n (%) |
|
|
|
|
| R0, n (%) |
40 (44%) |
10 (25%) |
30 (75%) |
|
| R1, n (%) |
52 (56%) |
17 (33%) |
35 (67%) |
0.422 |
| Degree of differentiation |
|
|
|
|
| Grade I, II |
53 (58%) |
9 (17%) |
44 (83%) |
|
| Grade III, IV |
39 (42%) |
18 (46%) |
21 (54%) |
0.002 |
| Type of differentiation |
|
|
|
|
| Pancreaticobiliary, n (%) |
84 (91%) |
27 (32%) |
57 (68%) |
|
| Intestinal, n (%) | 8 (9%) | 0 (0%) | 8 (100%) | 0.099b |
PC, pancreatic adenocarcinoma.
aChi-square test, when not otherwise specified.
bFisher’s Exact Test.
cLNR assessment of 91 patients since in one specimen no lymph nodes were retrieved.