. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2014 Jun 6;7(4):620–625. doi: 10.1161/CIRCEP.113.001244

Table 2.

Adjusted^* hazard ratios (95% confidence intervals) for the association between categories of overweight and obesity with risk of incident atrial fibrillation (AF) in men and women in the Atherosclerosis Risk in Communities Study (ARIC), 1987 – 2009

	Body mass index (kg/m²)

	18.5–24.9 (Ref)	25–29.9 (Overweight)		≥30 (Obese)	P_trend^**

n	4650	5667		3902
AF cases	444	690		641
HR (95% CI)	1.00	1.20 (1.06–1.36)		1.95 (1.72–2.21)	<0.0001

	Waist circumference (quartiles)

	1^st (Ref)	2^nd	3^rd	4^th	P_trend^**

n	3696	3665	3441	3417
AF cases	293	375	476	631
HR (95% CI)	1.00	1.18 (1.01–1.37)	1.52 (1.31–1.76)	2.13 (1.85–2.46)	<0.0001

Adjusted for age, sex, race, study site, education, income, prior cardiovascular disease, cigarette smoking, height, physical activity and alcohol consumption.

^**

Linear trend by body mass index group or waist circumference quartiles as an ordinal variable. Non-significant sex interaction between BMI categories and risk of atrial fibrillation (p = 0.34) and between waist circumference and risk of atrial fibrillation (p = 0.76). Sex specific quartiles for WC in men (women) were ≤ 92 (≤ 84) cm, 93 –98 (85 – 94) cm, 99 – 105 (95 – 105) and ≥ 106 (≥106) cm.