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. 2014 Oct 27;7:32. doi: 10.1186/1756-8935-7-32

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© Park et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Loss of Chd1 leads to changes in local occupancy of RNAPII Ser 5-P. (A) Wide view shows no large-scale occupancy changes of either form of elongating RNAPII between wild-type (WT) and chd1Δ. (B) Close-up of highly transcribed genes showing that RNAPII Ser 5-P shifts upstream in chd1Δ, but RNAPII Ser 2-P peaks appear very similar between WT and chd1Δ. (C) shapeDiff quantification of the peak shape similarity of RNAPII Ser 5-P and RNAPII Ser 2-P between WT and chd1Δ. The effect of CHD1 deletion on changes in peak shape is much stronger for RNAPII Ser 5-P than for RNAPII Ser-2 P.