Table 3.
Multivariable Cox regression analyses for the composite outcome
| |
Model 1 |
Model 2 |
Model 3 |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Sex (vs. female) |
0.658 (0.189 – 2.292) |
0.511 |
0.821 (0.215 – 3.132) |
0.773 |
0.741 (0.175 – 3.149) |
0.685 |
| Age (per 1 year increase) |
0.952 (0.914 – 0.992) |
0.020 |
0.950 (0.911 – 0.991) |
0.017 |
0.945 (0.902 – 0.991) |
0.019 |
| HTN (vs. no) |
0.675 (0.184 – 2.476) |
0.553 |
0.793 (0.194 – 3.242) |
0.746 |
0.663 (0.138 – 3.198) |
0.609 |
| TAP (per 1 g/g increase) |
1.887 (1.399 – 2.546) |
<0.001 |
1.881 (1.392 – 2.543) |
<0.001 |
1.979 (1.382 – 2.832) |
<0.001 |
| eGFR (per 1 ml/min/1.73 m2 increase) |
0.955 (0.932 – 0.979) |
<0.001 |
0.951 (0.923 – 0.978) |
0.001 |
0.952 (0.926 – 0.978) |
<0.001 |
| Pathologic variants |
|
|
|
|
|
|
| NOS |
– |
– |
Reference |
|
Reference |
|
| Perihilar |
– |
– |
1.054 (0.189 – 5.862) |
0.952 |
1.019 (0.183 – 5.664) |
0.983 |
| Tip |
– |
– |
1.699 (0.160 – 18.052) |
0.660 |
1.657 (0.162 – 16.949) |
0.670 |
| Immunosuppression (vs. no) | – | – | 0.622 (0.120 – 3.225) | 0.572 | ||
Abbreviations:HTN hypertension, eGFR estimated glomerular filtration rate, TAP time-averaged proteinuria.
Model 1: sex, age, hypertension, TAP, and eGFR.
Model 2: Model 1 + pathologic variants.
Model 3: Model 2 + immunosuppression.